Treatment options in gastrointestinal bleeding caused by toxic doses of new generation oral anticoagulants: single center experience and case series
Mustafa Yıldırım1, Emin Taşkıran1, Semih Gülle1, Muhammed Ali Kaypak1, Utku Erdem Soyaltın1, Harun Akar1, Cengiz Ceylan2, Coşkun Yıldız3
1İzmir Tepecik Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İzmir, Türkiye
2İzmir Tepecik Eğitim ve Araştırma Hastanesi, Hematoloji Kliniği, İzmir, Türkiye
3İzmir Tepecik Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir, Türkiye
Keywords: Dabigatran; dabigatran toxicity; gastrointestinal hemorrhage.
Abstract
Dabigatran, which is one of the new generation oral anticoagulants, is a direct thrombin inhibitor and is eliminated by renal clearance. The treatment modalities to be used in dabigatran toxicity is unclear. In this article, we evaluated the efficacies of treatment modalities consisting of factor concentrate infusion, fresh frozen plasma infusion, and hemodialysis performed in three patients who were using dabigatran due to non-valvular atrial fibrillation and who developed gastrointestinal hemorrhage. One of three patients died, the other two were healed.