Elif Özyılmaz1, Özge Çağlar1,2, Sebahat Aşcıoğlu1, Merve Bezgin1, Mukaddes Saklan1, Handan Sağlam1, Oytun Erbaş3

1Department of Biochemistry, Selçuk University, Faculty of Science, Konya, Turkey
2Department of Chemistry, Selçuk University, Faculty of Science, Konya, Turkey
3Department of Physiology, Demiroğlu Science University, Faculty of Medicine, Istanbul, Turkey

Keywords: Curcumin, iron oxide nanoparticles, magnetic nanoparticles, turmeric.


Objectives: In this study, it was aimed to obtain curcumin from the extracts of the turmeric plant by using a simple and fast magnetic separation method, unlike other standard methods.

Materials and methods: Magnetic iron oxide nanoparticles (IONPs) were prepared by chemical co-precipitation of Fe3+ and Fe2+ ions. Magnetic nanoparticles were used to extract curcumin from turmeric. In addition, curcumin was characterized and compared with commercial curcumin. Curcumin was recovered by purifying it from extracts of the turmeric plant.

Results: Fe3O4 nanoparticles were characterized using transmission electron microscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy, and Ultraviolet (UV)-visible spectra. Transmission electron microscopy analysis was used to describe the particle size and surface morphology of Fe3O4 nanoparticles, and the XRD device was used to explain X-ray diffraction. Curcumin was extracted from turmeric plant extracts purified with Fe3O4 nanoparticles. Fourier-transform infrared spectroscopy was used to determine the functional groups in the structure of turmeric, Fe3O4 nanoparticles, Fe3O4 turmeric complex, commercial curcumin, and curcumin. The UV spectrum of commercial curcumin and curcumin was also examined using the Shimadzu UV-1700 Pharma spectrophotometer. It has been established that it is recovered with a purification yield of 1.5 percent following purification.

Conclusion: These results suggest that curcumin, which has research potential in the field of health, may also be beneficial in terms of creating different scientific and economic expansions and producing new studies.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

This study was supported with the application number 1919B011902144 within the scope of Scientific and Technological Research Council of Turkey (TUBITAK)/BIDEB/2209-A University Students Research Projects Support Program.


We would like to thank TUBITAK and Selcuk University for their support.