Rafet Bilgiç1, Atakan Özdoğan1, Alican Yürük1, Birsen Gizem Özamrak2, Harun Akar1

1Department of Internal Medicine, Tepecik Training and Research Hospital, Izmir, Türkiye
2Department of Pathology, Tepecik Training and Research Hospital, Izmir, Türkiye

Keywords: Amyloidosis, ankylosing spondylitis, chronic kidney disease.


Ankylosing spondylitis (AS) is one of the most common causes of secondary amyloidosis. Amyloidosis is a systemic disease, it may present with different symptoms and signs. The diagnosis of amyloidosis can be made with renal biopsy in patients who have proteinuria and regression in renal functions. Development of symptoms such as chronic diarrhea in patients which suggest gastrointestinal involvement, taking biopsy with endoscopy and colonoscopy imaging can again diagnose amyloidosis. The accumulation of amyloid in the organs may take time, so sometimes suspicious positivity may prolong the process for patients to be diagnosed with amyloidosis. We report the case of a 58-year-old male patient with long-standing AS, presenting with secondary amyloidosis, chronic diarrhea, proteinuria, and renal dysfunction.

Cite this article as: Bilgiç R, Özdoğan A, Yürük A, Özamrak BG, Akar H. AA amyloidosis secondary to uncontrolled and untreated ankylosing spondylitis manifested by chronic diarrhea, sacroileitis, and chronic kidney disease. D J Med Sci 2023;9(2):78-81. doi: 10.5606/fng.btd.2023.129.

Author Contributions

Idea/concept, design, data collection and/or processing, Literature review, writing the article, critical review, references and fundings, materials: R.B.; Idea/concept, data collection and/or processing: A.Ö.; Idea/concept, data collection and/or processing: A.Y.; Idea/concept, writing the article, materials: B.G.Ö.; Control/supervision, critical review, literature review, writing the article, analysis and/or interpretation: H.A.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.