The method of peripheral stem cell collection and its effect on the donor

Abstract

Stem cells are the cells that are capable of forming all of the tissues and organs in our body. Certain diseases can be treated by stem cell transplantation. There are three types of stem cell transplantation: syngeneic, autologous, and allogeneic. In allogeneic transplantation, stem cells are obtained from a donor with or without blood relation. Sources such as bone marrow, peripheral blood, and cord blood are used to obtain stem cells. Peripheral stem cell collection is the most common and preferred method of stem cell collection. To obtain stem cells, the bone marrow must first be stimulated with the mobilization drug, which allows the stem cells to pass into the peripheral blood. The stem cells are then filtered from the donor’s blood with the help of an apheresis device. The process of deciding to become a donor until the collection of stem cells is very important. The donor is first subjected to a histocompatibility test followed by a physical fitness test for the procedure. The health of the donor is carefully checked during and after the procedure. In this study, the allogeneic method of peripheral stem cell collection and its effect on the donor will be emphasized. The process from the donor's application to the post-transplant period will be discoursed.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.