Genetically engineered mice models and generating glioblastoma multiforme in the brain
Yasin Polat
, Oytun Erbaş
Institute of Experimental Medicine, Kocaeli, Türkiye
Keywords: Cancer stem cells, central nervous system, genetically modified mouse models, glioblastoma multiforme, oncogenes.
Abstract
Glioblastoma multiforme (GBM) is a brain tumor that occurs in adults. It is one of the most common malignancies in the world and its incidence is increasing every year. Patients with GBM have a poor prognosis and treatment is largely based on the recurrence rate. In this review, we examine therapeutic modalities against GBM using genetically modified mouse models, which play an important role in cancer research.
Cite this article as: Polat Y, Erbaş O. Genetically engineered mice models and generating glioblastoma multiforme in the brain. D J Med Sci 2024;10(1):55-61. doi: 10.5606/fng.btd.2024.147.
All authors contributed equally to the article.
Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.
The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.
The authors received no financial support for the research and/or authorship of this article.