Antiapoptotic and insulin-releasing effects of zinc supplementation in type-1 diabetes through ATP sensitive potassium channels
Celal Güven1, Şahin Yeşildağ2, Özge Özdemir3, Talar Cilacı
1Ömer Halisdemir Üniversitesi Tıp Fakültesi Biyofizik Anabilim Dalı, Niğde, Türkiye
2İstanbul Bilim Üniversitesi Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü, İstanbul, Türkiye
3İstanbul Bilim Üniversitesi Sağlık Hizmetleri Meslek Yüksekokulu, Fizyoterapi ve Rehabilitasyon Programı, İstanbul, Türkiye
4Bezmi Alem Üniversitesi Sağlık Bilimleri Fakültesi Ergoterapi Bölümü, İstanbul, Türkiye
5Ömer Halisdemir Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Niğde, Türkiye
Keywords: Adenosine triphosphate sensitive potassium channel; apoptosis; diabetes mellitus; metallothionein; oxidative stress; zinc supplementation.
Abstract
Diabetes, which is a frequently observed disease in the overall world, is the defect of glucose metabolism due to insulin deficiency. Decreased insulin is not sufficient to transport the glucose we receive through nutrition to the cells. As part of the treatment of insulin-dependent diabetes, known as type 1 diabetes, attempts are made on recovering the pathologies developing due to the disease by performing insulin injection. Zinc is an element of trace amount in our body. Although its effects in secretion of insulin have still not been clarified thoroughly, it functions in insulin packaging and secretion particularly in beta-cells. Mechanism of action or pathways of zinc on insulin secretion still remains a mystery. Under normal circumstances, adenosine triphosphate (ATP) sensitive potassium (KATP) plays a key role in the secretion of insulin from beta-cells. It is claimed that zinc may somehow block KATP activity.