Comparison of clinicopathological and demographic features of early and late phase gastric cancer patients
Utku Erdem Soyaltın1, Cemil Bilir2, Yasemin Bakkaltemi2, İbrahim Başarır1, Yücel Üstündağ1, Selim Aydemir1, Hüseyin Engin2
1Zonguldak Karaelmas Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Zonguldak, Türkiye
2Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Bilim Dalı, Zonguldak, Türkiye
Keywords: Clinicopathological; demographic differences; gastric cancer; prognostic factors.
Objectives: Comparison of clinicopathological and demographic features of early and late stage gastric cancer patients and determination of prog- nostic factors that specific for late stage patients.
Patients and methods: Files of 145 patients diagnosed with adenocarcinoma, operated at Zonguldak Karaelmas University School of Medicine Training and Research Hospital were examined retrospectively.
Results: There were 19 early-stage patient. Lymph node involvement of two patients was positive. Three patients had been died non-cancer related causes. Average follow-up time was 58.7 months for 16 patient. Average survey of late stage patients were 26.10 months. The factors that affect survey statistically significant were determined as age, T-N score and number of lymph node that removed. Prognostic factors that specific to the stages were examined: age and lymph node number that removed for stage 2, age, macroscopic image, taking chemotherapy, size and differentiation degree for stage 3, size for stage 4 was determined as a factors that effect to survey.
Conclusion: In our study, depth of invasion was associated with lymph node positivity in early stage. The detection of number of lymph node resec- tion as a prognostic factor in late stage might be due to insufficient lymph node dissection to 46 of 126 patients. Lack of statistical difference in terms of survey between stages 3-4 may be due to incorrect staging because of lower lymph node removal in stage 3 than stage 4 and extension of survey because of removal of more lymph nodes in stage 4.