Evaluation of thrombotic thrombocytopenic purpura cases: A single-center experience
Cengiz Ceylan1, Şeyma Hızarcı2, Gülin Keskin3, Damla Çağla Patır3, Aybüke Olgun1
1Department of Hematology, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey
2Therapeutic Apheresis Unit, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey
3Department of Internal Medicine, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey
Keywords: Idiopathic thrombotic thrombocytopenic purpura, plasmapheresis, plasmic score
Abstract
Objectives: In this study, we aimed to analyze the laboratory data of patients with idiopathic thrombotic thrombocytopenic purpura (TTP).
Patients and methods: A total of 20 patients (7 males, 13 females; median age 42.5 years, range 20 to 75 years) diagnosed with idiopathic TTP were retrospectively evaluated. Age, sex, median plasmapheresis count, LDH, platelet count, hemoglobin, hematocrit, indirect bilirubin levels, and treatment responses of the patients were assessed. Groups were formed according to plasmic score.
Results: Lactate dehydrogenase (LDH) levels before and after plasmapheresis, on day 1, 3, and 7, total and indirect bilirubin levels, creatinine, AST/ALT, hemoglobin, leukocyte values, and platelet counts were compared. The median LDH levels of patients regressed to normal in an average of three days (range: 1-19). Mean platelet count was 47,100/μL at admission. Platelet count returned to normal in a median of 7 (3-32) days. The median number of plasmapheresis procedures was 8.5 (5-58). All patients underwent prednisolone treatment. Three patients died, in which one had severe neurological involvement. Mortality rate was 15%.
Conclusion: In the treatment of TTP, monitoring of LDH, platelet count and bilurubin values is important in evaluating the treatment response of plasmapheresis process. Further studies involving patient data are needed for the plasmic score used to assess severe idiopathic ADAMTS13 deficiency.
Cite this article as: Ceylan C, Hızarcı Ş, Keskin G, Çağla Patır D, Olgun A. Evaluation of thrombotic thrombocytopenic purpura cases: A single-center experience. FNG & Demiroğlu Bilim Tıp Dergisi 2019;5(3):119-123.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.