Tülin Akagün1, Arzu Ayraler2, Murat Usta3, Süleyman Baylan4, Ahmet Cumhur Dülger5

1Department of Nephrology, Tulin Akagun, Giresun University Faculty of Medicine, Giresun, Türkiye
2Department of Family Medicine, Arzu Ayraler, Giresun University Faculty of Medicine, Giresun, Türkiye
3Department of Biochemistry, Murat Usta, Giresun University Faculty of Medicine, Giresun, Türkiye
4Department of Internal Medicine, Süleyman Baylan, Giresun University Faculty of Medicine, Giresun, Türkiye
5Department of Gastroenterology, Ahmet Cumhur Dülger, Giresun University Faculty of Medicine, Giresun, Türkiye

Keywords: Acute kidney injury, COVID-19, neutrophil lymphocyte ratio, prognostic nutritional index.


Objectives: The aim of this study was to evaluate the clinical features and outcomes of patients with coronavirus disease 2019 (COVID-19) who experienced acute kidney injury (AKI) during intensive care unit (ICU) hospitalization.

Materials and methods: Between March 01, 2020 and June 30, 2020, a total of 49 patients (28 males, 21 females; mean age: 75.5±12.5 years; range, 21 to 92 years) with COVID-19 PCR positive who were hospitalized with COVID-19 pneumonia in the ICU and developed AKI were evaluated with demographics, laboratory data, treatment, and outcome. The prognostic nutritional index (PNI), which is calculated using the serum albumin concentration and the total lymphocytic count was also evaluated. All patients were treated with favipiravir+low molecular weight heparin; laboratory tests were recorded before and after favipiravir treatment.

Results: Nine (18.4%) patients survived to hospital discharge. The mean PNI of the patients who survived was higher than in non-survivors. Lactate dehydrogenase (LDH), procalcitonin, ferritin, and C-reactive protein (CRP) results were higher in non-survivors. When we compare the PNI results, the mean PNI was lower after the favipiravir treatment. Leucocyte, neutrophil count, and neutrophil-lymphocyte ratio results were higher after the treatment. Creatinine, LDH, procalcitonin, ferritin, and CRP results were higher after the treatment in non-survivors.

Conclusion: Acute kidney injury was related to a significant mortality rate in COVID-19 hospitalized patients. Prognostic nutritional index may be a valuable clinical marker for predicting survival in COVID-19 patients.

Cite this article as: Akagün T, Ayraler A, Usta M, Baylan S, Dülger AC. Acute kidney injury in hospitalized patients with COVID-19: A single center experience. D J Med Sci 2022;8(3):115-119.

Ethics Committee Approval

The study protocol was approved by the Gumushane University Ethics Committee (date: 23.02.2022, no: 2022/1). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Author Contributions

Idea/design and article writing: T.A.; Literature review: A.A.; Statistical analysis: M.U.; Data collection/data entry: S.B.; Critical review: A.C.D.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.