Platelet mediated cancer modulation: A comprehensive review from biological mechanisms
Fatime Akgeyik1
, Alper Demirezen2, Oytun Erbaş2
1Department of Molecular Biology and Genetics, Ahi Evran University, Kırşehir, Türkiye
2Institute of Experimental Medicine, Kocaeli, Türkiye
Keywords: Biology, cancer, medicine, platelets, treatment.
Abstract
Deciphering the molecular details of platelets' interactions with cancer cells is crucial, as evidenced by their identification as active participants in the metastatic cascade. This information not only improves our understanding of the complexity of cancer biology, but it also points to possible directions for therapeutic intervention. Targeting and identifying the important molecular actors in the interactions between cancer and platelets presents a possible avenue for novel cancer therapies. Intriguing topics for more research include the effect of platelets on the immune system and their possible role in cancer cells' immunological evasion. Future approaches to cancer immunotherapy may be reshaped by the intricate interactions between platelets and the immune system. Comprehending the intricate roles played by platelets in the development of cancer is becoming more and more important as personalized treatment gains traction. Therapeutic approaches take on a new dimension with the potential to incorporate platelet regulation into cancer therapy regimens. Nevertheless, in order to further our understanding of the relationships between platelets and cancer, future research should include other factors, such as perinatal and prenatal impacts. This review highlights the importance of platelets within the framework of cancer biology, providing opportunities for more research and practical use.
Cite this article as: Akgeyik F, Demirezen A, Erbaş O. Platelet mediated cancer modulation: A comprehensive review from biological mechanisms. D J Med Sci 2023;9(3):142-149. doi: 10.5606/fng.btd.2023.135.
Provided the idea, concept, authors and extensive literature review of this comprehensive review: F.A., A.D.; Has supervised and critically reviewed this article with his pioneering ideas and opinions: O.E.
Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.
The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.
The authors received no financial support for the research and/or authorship of this article.