Prion proteins and their impact on memory: A complex relationship
Kübra Nur Şahin1
, Oytun Erbaş2
1Molecular Biology and Genetics, Yıldız Technical University, İstanbul, Türkiye
2Institute of Experimental Medicine, Gebze-Kocaeli, Türkiye
Keywords: Memory, memory formation, prion diseases, prion-like proteins, prion protein.
Abstract
Prion proteins are significant proteins located on the surface of mammalian cells, closely associated with the nervous system. They were first discovered in the context of fatal neurodegenerative diseases known as prion diseases. In these diseases, a pathological form of the cellular prion protein, known as scrapie prion protein, which exhibits a beta-sheet-rich structure, is observed. Although the exact function of prion proteins is not yet fully understood, there is growing speculation about their potential role in memory formation and long-term memory processes. In this review, we address prion proteins, prion-like proteins, and their relationship with memory processes.
Cite this article as: Şahin KN, Erbaş O. Prion proteins and their impact on memory: A complex relationship. D J Med Sci 2024;10(3):159-166. doi: 10.5606/fng. btd.2024.165.
Idea/concept, data collection and/or processing, analysis and/or interpretation, literature review, writing the article: G.D.S.; Control/supervision: O.E.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.