Can increased mean platelet volume predict high mortality in intensive care patients?

Abstract

Objectives: This study aims to investigate the effect of Acute Physiology and Chronic Health Evaluation II (APACHE II) score and mean platelet volume (MPV) on mortality rate in patients at intensive care unit (ICU).
Patients and methods: A total of 120 patients hospitalized at ICU between February 2016 and August 2016 were evaluated retrospectively. Patients with active hematological malignancy were excluded from the study. Remaining 115 patients (51 males, 64 females; mean age 63.7±115 years; range 29 to 89 years) were included. Mean platelet volume values in complete blood count and APACHE II scores during admission to ICU, and duration of stay at ICU of patients with or without invasive mechanical ventilation were calculated.
Results: Of the patients, 56 died at ICU, while 59 were transferred to clinic with recovery. Mortality rate of patients was 48.6%. Mean APACHE II score of surviving patients (12.6±1.2) was significantly lower than the score of patients who died (22.2±1.3) (p<0.001). Mean platelet volume values in surviving and dead patients were 7.84±1.41 fL and 10.08±1.30 fL, respectively and the difference in between was statistically significant (p=0.01).
Conclusion: Results of our study showed that increased MPV value in intensive care patients may be associated with high mortality rate.