Retrospective study of fatal and recovered COVID-19 cases in the intensive care unit of Manavgat State Hospital
Işıl Deniz Alıravcı1
, Malik Çoraklı2, Duygu Sıddıkoğlu3
1Infectious Diseases and Clinical Microbiology, Çanakkale 18 Mart University Health Practice and Research Hospital, Çanakkale, Türkiye
2Department of Radiology, Manavgat State Hospital, Antalya, Türkiye
3Department of Biostatistics, Çanakkale 18 Mart University Health Practice and Research Hospital, Çanakkale, Türkiye
Keywords: COVID-19, CRP, intensive care units, Manavgat, non-survivors, survivors.
Abstract
Objectives: In this study we aimed to describe the clinical features, treatment, and outcomes of patients with COVID-19 admitted to the intensive care unit.
Patients and methods: In this retrospective, observational study, we enrolled 116 patients (69 males, 47 females; mean age: 66.9±13.6 years; range, 23 to 93 years) with COVID-19 confirmed by PCR tests who were admitted to Manavgat State Hospital. Demographic data, symptoms, laboratory findings, comorbidities, treatment, and outcomes were collected between August 1, 2020, and January 1, 2021. Data were compared between patients who died and those who survived.
Results: A total of 62 patients died, with a 53.4% mortality rate, while 54 recovered. The demographic analysis indicated that mortality for patients in the older age group (i.e., ≥60 years) was higher than those in the younger age group (84%, 68.5%). In addition, seven laboratory parameters were statistically associated with mortality: neutrophil (p<0.001), C-reactive protein (p<0.001), urea (p<0.001), lactate dehydrogenase (p<0.001), ferritin (p<0.001), D-dimer (p<0.001), and Troponin-I (p<0.001). Sixty-three patients (55%) required mechanical ventilation, and only one patient (2%) survived after mechanical ventilation. The median time from intensive care unit admission to death was 11.5 days (interquartile range 7.0-17). At 28 days and 60 days, 57 (49%) and four (3.5%) patients died, respectively. On the 72nd day, one (0.9%) patient died.
Conclusion: Neutrophil, C-reactive protein, urea, lactate dehydrogenase, ferritin, D-dimer, and Troponin-I counts were found to be predictive of death in these patients. Further studies are needed to aid efficient recognition and management of severe COVID-19 patients in our population.
Cite this article as: Alıravcı ID, Çoraklı M, Sıddıkoğlu D. Retrospective study of fatal and recovered COVID-19 cases in the intensive care unit of Manavgat State Hospital. D J Med Sci 2022;8(1):11-18.
This study was approved by the medical ethics committee of Çanakkale 18 Mart University, Faculty of Medicine 113 (07/12.11.2020). The study was conducted in accordance with the principles of the Declaration of Helsinki.
Informed consent was waived because of the retrospective design of the study, and the researchers analyzed the anonymized data.
Data Sharing Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Collected the data and corresponding writer: I.D.A.; Collected the data: M.Ç.; Performed statistical analysis: D.S.
The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.
The authors received no financial support for the research and/or authorship of this article.