Exploring hormonal dynamics in obesity: Leptin, ghrelin, and nesfatin-1

Abstract

Obesity is a disease that develops as a result of multifactorial causes such as genetic, environmental, biological, psychosocial, and economic factors, leading to excessive fat accumulation and a body mass index exceeding 30 kg/m². In our bodies, there are appetite-stimulating and suppressing hormones that regulate nutrient intake and control energy metabolism, either directly secreted or via the hypothalamus. This review examines the relationships between obesity and major appetite-suppressing hormones, including the protein-based leptin hormone synthesized from adipose tissue and nesfatin-1, a neurohormone expressed from adipose tissue, pancreas, and brain, as well as ghrelin, a peptide hormone also known as an appetite stimulant.

Cite this article as: Yayla MA, Erbaş O. Exploring hormonal dynamics in obesity: Leptin, ghrelin, and nesfatin-1. D J Med Sci 2024;10(1):26-33. doi: 10.5606/fng. btd.2024.142.

Writer of article: M.A.Y.; Supervisor: O.E.

Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.

The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.

The authors received no financial support for the research and/or authorship of this article.