Tetracycline antibiotics: Emerging roles in neuropsychiatric disorders

Abstract

Tetracyclines are broad-spectrum antibiotics used primarily for bacterial infections and various other conditions. Experimental studies have demonstrated their neurogenesis-inducing, neuroprotective, antioxidant, antinociceptive, antiapoptotic, and anti-glutamate-induced excitotoxicity properties. Due to these attributes, it is believed that when combined with antipsychotic medications used in psychiatric disorders, tetracyclines may facilitate the treatment of conditions such as autism spectrum disorder (ASD), major depressive disorder (MDD), and schizophrenia. This review article examines the biochemical structure, pharmacokinetic, and pharmacodynamic properties of the tetracycline group of antibiotics, as well as their uses in various diseases. It particularly focuses on the neuroprotective, antioxidant, antinociceptive, antiapoptotic, and anti-glutamate-induced excitotoxicity properties of minocycline. Additionally, the potential use of minocycline in the treatment of psychiatric disorders such as ASD, MDD, and schizophrenia is discussed.

Cite this article as: Şiva Acar A, Saday Ö, Erbaş O. Tetracycline antibiotics: Emerging roles in neuropsychiatric disorders. D J Med Sci 2024;10(2):74-82. doi: 10.5606/fng. btd.2024.149.

All authors contributed equallyto this article.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.

Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.