The four horsemen of neurodegenerative diseases Alzheimer, Parkinson, Huntington and amyotrophic lateral skleroz; clinical definition and experimental models
Canberk Tomruk1, Cansın Şirin1, Aylin Buhur1, Kubilay Doğan Kılıç1, Emel Öykü Çetin2, Oytun Erbaş3 Yiğit Uyanıkgil1
1Ege Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, İzmir, Türkiye
2Ege Üniversitesi Eczacılık Fakültesi Biyofarmasotik Farmakokinetik Anabilim Dalı, İzmir, Türkiye
3İstanbul Bilim Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, İstanbul, Türkiye
Keywords: Experimental models; neurodegeneration; neurodegenerative diseases.
Abstract
Along with the increase in the life span in the world and our country, the elderly population brings with different problems. During this life span destruction of nerve cells and clinical manifestations revealing after that constitute the group of diseases called "neurodegenerative diseases". Some neurodegenerative diseases are related to genetic factors rather than age. The emergence mechanisms of these diseases and development of new therapies are only possible by establishing experimental models capable of work in experimental animals. In this review, clinical features of neurogenerative diseases and pharmalogical/transgenic methods used in experimental model of neurodegenerative diseases will be mentioned.